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The Tainted Plague

Source Pathfinder Campaign Setting pg. 149
Type contact; Fortitude Save DC 15 (see description)
Onset 1 day; Frequency 1/day
Effect 1d6 Con and 1d6 Wis
Cure 2 consecutive saves
Even in the absence of ravening abyssal hordes, the Worldwound causes a supernatural disease called the tainted plague. Those exposed to the Worldwound or creatures native to it (including creatures already suffering ability damage from the disease) must make a DC 15 Fortitude save once per day or become infected. Those reduced to 0 Wisdom are driven mad by the mind-bending horrors they have witnessed. Those reduced to 0 Constitution perish, their bodies rotting from the inside out and dissolving within 24 hours into primordial chaos matter.

Creatures that do not need to breathe gain a +2 bonus on saves made to resist the tainted plague, but any creature eating or drinking anything from within the Worldwound must save immediately at a suffers a –5 penalty unless purify food and drink is first used.